Anti-spasmogenic effect of cyproheptadine on guinea-pig ileum.
نویسندگان
چکیده
Antagonistic activity of cyproheptadine against common spasmogens, like acetylcholine, histamine, serotonin, bradykinin and angiotensin, was studied on isolated guinea-pig ileum. Cyproheptadine produced a reversible antagonism of non-competitive type and was most effective against serotonin. It was less potent against histamine, bradykinin and angiotensin and least potent against acetylcholine.
منابع مشابه
Effect of Matricaria chamomilla extract on the electrically stimulation of ileum of guinea-pig in invitro model
Previous studies indicate that Matricaria chamomilla (MC), a folk remedy plant, is very useful in the treatment of spasmogenic bowel diseases but the way of its action is not clear. For this purpose, we studied the effect of MC extract on the electrically activation in Guinea-Pig ileum in an invitro model. We used guinea pig in this study. After of kill, we brouhght out a piece of ileum and fix...
متن کاملEffect of Matricaria chamomilla extract on the electrically stimulation of ileum of guinea-pig in invitro model
Previous studies indicate that Matricaria chamomilla (MC), a folk remedy plant, is very useful in the treatment of spasmogenic bowel diseases but the way of its action is not clear. For this purpose, we studied the effect of MC extract on the electrically activation in Guinea-Pig ileum in an invitro model. We used guinea pig in this study. After of kill, we brouhght out a piece of ileum and fix...
متن کاملStudies on the presence of spasmogenic and spasmolytic constituents in Hibiscus rosasinensis aerial parts
The aqueous-ethanolic extract of the Hibiscus rosasinensis aerial parts (Hr.Cr) was studied for the possible presence of spasmogenic and spasmolytic constituents to rationalize some of its traditional uses in gastrointestinal disorders. Segments of isolated rabbit jejunum and guinea-pig ileum, 2-3 cm long were mounted seprately in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide....
متن کاملStudies on the presence of spasmogenic and spasmolytic constituents in Hibiscus rosasinensis aerial parts
The aqueous-ethanolic extract of the Hibiscus rosasinensis aerial parts (Hr.Cr) was studied for the possible presence of spasmogenic and spasmolytic constituents to rationalize some of its traditional uses in gastrointestinal disorders. Segments of isolated rabbit jejunum and guinea-pig ileum, 2-3 cm long were mounted seprately in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide....
متن کاملEffect of aqueous fraction of Rosa damascena on ileum contractile response of guinea pigs
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 27 4 شماره
صفحات -
تاریخ انتشار 1983